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Comoros Stun Ghana, Togo Hold Champions Senegal
While Cameroon and Senegal were forced to settle for draws away from home.
Ghana were beaten 1-0 by Comoros in their Group I contest in Moroni through Myziane Maolida’s fine solo effort two minutes before half-time.
Ghana were unconvincing as they beat Madagascar in their opener on Friday but boss Chris Hughton dropped Mohammed Kudus to the bench as he chose to restore captain Andre Ayew to the starting XI.
Comoros had beaten the Black Stars 3-2 at the 2021 AFCON in Cameroon
to dump the West Africans out of the tournament last year, and lightning struck twice as the Coelacanths moved on to six points at the top of Group I, two ahead of Mali and three above Ghana.
Elsewhere, Senegal were held to a goalless draw by Togo in Lome while Libya fought back to draw 1-1 with Cameroon in front of a fervent crowd in Benghazi.
There were also wins for Tunisia, Burkina Faso, Cape Verde, Uganda and Namibia.
Morocco, who became the first African side to reach the World Cup semi-finals in Qatar last year, played their first qualifier away against Tanzania and Zambia seek a second straight win away against Niger in neutral Marrakesh.
Africa will have a guaranteed nine teams at the expanded 2026 finals in Canada, Mexico and the United States, with the chance of a 10th team to qualify via intercontinental play-offs.